The United States has seen a dramatic reduction in the number of travelers from China, especially from Hubei province. 6, 7Ĭhina, the United States, and several other countries have instituted temporary restrictions on travel with an eye toward slowing the spread of this new disease within China and throughout the rest of the world. Recent reports of high titers of virus in the oropharynx early in the course of disease arouse concern about increased infectivity during the period of minimal symptoms. As the authors note, until this number falls below 1.0, it is likely that the outbreak will continue to spread. The current study indicates an estimated basic reproduction number (R 0) of 2.2, which means that, on average, each infected person spreads the infection to an additional two persons. The efficiency of transmission for any respiratory virus has important implications for containment and mitigation strategies. This suggests that the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%) or a pandemic influenza (similar to those in 19) rather than a disease similar to SARS or MERS, which have had case fatality rates of 9 to 10% and 36%, respectively. If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%. 5 report mortality of 1.4% among 1099 patients with laboratory-confirmed Covid-19 these patients had a wide spectrum of disease severity. 4 In another article in the Journal, Guan et al. On the basis of a case definition requiring a diagnosis of pneumonia, the currently reported case fatality rate is approximately 2%. Either children are less likely to become infected, which would have important epidemiologic implications, or their symptoms were so mild that their infection escaped detection, which has implications for the size of the denominator of total community infections. Of note, there were no cases in children younger than 15 years of age. The median age of the patients was 59 years, with higher morbidity and mortality among the elderly and among those with coexisting conditions (similar to the situation with influenza) 56% of the patients were male. Nonetheless, a degree of clarity is emerging from this report. Although this information is critical in informing the appropriate response to this outbreak, as the authors point out, the study faces the limitation associated with reporting in real time the evolution of an emerging pathogen in its earliest stages. In their Journal article, Li and colleagues 3 provide a detailed clinical and epidemiologic description of the first 425 cases reported in the epicenter of the outbreak: the city of Wuhan in Hubei province, China. As in two preceding instances of emergence of coronavirus disease in the past 18 years 2 - SARS (20) and Middle East respiratory syndrome (MERS) (2012 to the present) - the Covid-19 outbreak has posed critical challenges for the public health, research, and medical communities. 1 It was rapidly shown to be caused by a novel coronavirus that is structurally related to the virus that causes severe acute respiratory syndrome (SARS). Covid-19 was recognized in December 2019.
Uncharted 2020 movie#
Original Nathan Drake voice actor Nolan North also shared a few images from the set, which appears to prove that the Uncharted movie - which, at least for now, is still being directed by Ruben Fleischer - is, in fact, a real film that is actually in production and could one day be something you’ll get to watch in theaters.The latest threat to global health is the ongoing outbreak of the respiratory disease that was recently given the name Coronavirus Disease 2019 (Covid-19).
That’s especially true when compared to other live-action interpretations of the character in media like Sony commercials or a particularly good fan film that starred Nathan Fillion and Stephen Lang as pitch-perfect replicas of Drake and his mentor Sully. The movie is reportedly set to be a prequel / origin story for the character.īut it’s still a jarring shift for anyone accustomed to the older Nathan Drake. Given that the Nathan Drake in the Uncharted games is in his mid- to late-30s, that’s not too surprising. It’s also hard not to fixate on the fact that 24-year-old Holland, looks, well, young in his first appearance as Nathan Drake. #unchartedĪ post shared by Tom Holland on at 7:46am PDT